Faculty & Staff
David Lin, Ph.D.
Integrated mechanical properties of skeletal muscle and spinal reflexes
Office: 211 Wegner Hall 📞509-335-7534
Lab: McCoy South 108 (📞509-335-7793)
The Gene and Linda Voiland
School of Chemical Engineering and Bioengineering
1505 Stadium Way, Room 105
P.O. Box 646515
Washington State University
Pullman, WA 99164-6515
Dr. Lin is interested in the integrated mechanical properties of skeletal muscle and spinal reflexes. Specifically, he studies how the individual components making up the peripheral neuromuscular system interact to stabilize posture while encountering a perturbation (e.g., an applied push to someone standing).
Dr. Lin’s research is applicable to Rehabilitation Medicine, specifically disorders of the nervous system, such as stroke or spinal cord injury, and investigating the underlying mechanisms of abnormal posture and movement. In addition, Dr. Lin also formulates mathematical models of skeletal muscle. Of particular interest to his laboratory are the force-generating characteristics of different muscle fiber types, which can be categorized by their unique proteins. By relating muscle protein content to mechanical function via mathematical models, different levels of study, from the molecular to the behavioral, can be connected.
Another aspect of his research is to incorporate the unique features of neuromuscular systems into engineered robotic systems. Unlike robots, humans remain stable while interacting with different loads, such as carrying varying weights. Implementing mechanical properties similar to muscle into the actuators of a robot may solve this problem.
Dr. Lin received a B.S. in Mechanical Engineering from the Massachusetts Institute of Technology in 1987. He completed the M.S. and Ph.D. degrees in Biomedical Engineering from Northwestern University in 1989 and 1997 respectively. From 1997 to 2000, he was a Postdoctoral Fellow both at Emory University in the department of Physiology and at the Georgia Institute of Technology in the department of Electrical and Computer Engineering. He accepted a joint appointment at Washington State University as assistant professor in the Departments of Veterinary and Comparative Anatomy, Pharmacology, and Physiology (VCAPP) and Department of Biological Systems Engineering in 2001.
- Darnall N.D., Donovan, C., Aktar, S., Tseng, H., Barthelmess, P., Cohen, P., and Lin, D.C. “Application of machine learning and numerical analysis to classify tremor in patients affected with essential tremor or Parkinson’s disease.” Gerontechnology. [In press].
- Lin, D.C., Hershey, J.D., Mattoon, J.S., and Robbins, C.T. “Muscles of hibernating brown bears are unusually resistant to effects of denervation.” Journal of Experimental Biology. [In press].
- Gollapudi, S.K. and Lin, D.C. “Experimental determination of sarcomere force-length relationship in type-I human skeletal muscle fibers.” Journal of Biomechanics. 42(13):2011–6, 2009.
- Vasavada, A.N., Lasher, R.A., Meyer, T.E., and Lin, D.C. “Defining and evaluating wrapping surfaces for MRI-derived spinal muscle paths.” Journal of Biomechanics. 41(7):1450–7, 2008.
- Hershey, J.D., Robbins, C.T., Nelson, O.L., and Lin, D.C. “Minimal seasonal alterations in skeletal muscle in captive brown bears.” Physiological and Biochemical Zoology. 81(2):138–47, 2008.
- Lin, D.C., Bucher B.P., Davis, H.P., and Sprunger, L.K. “A low-cost telemetry system suitable for measuring mouse biopotentials.” Medical Engineering and Physics. 30(2): 199–205, 2008.
- Lin, D.C. and Nichols, T.R. “Parameter estimation in a crossbridge muscle model.” ASME Journal of Biomechanical Engineering. 125(1): 132–140, 2003.
- Lin, D.C., and Rymer, W.Z. “Damping actions of the neuromuscular system with inertial loads: flexor pollicis longus muscle in man.” Journal of Neurophysiology. 85: 1059–1066, 2001.
- Lin, D.C., and Rymer, W.Z. “Damping actions of the neuromuscular system with inertial loads: soleus muscle of the decerebrate cat.” Journal of Neurophysiology. 83: 652–658, 2000.
- Nichols, T.R., Lin, D.C. and Huyghues-Despointes, C.M.J.I. “The role of musculoskeletal mechanics in motor coordination.” In: Peripheral and Spinal Mechanisms in the Neural Control of Movement, edited by M.D. Binder. Amsterdam: Elsevier Science, p. 369–378, 1999.
- Lin, D.C., and Rymer, W.Z. “Damping in reflexively active and areflexive lengthening muscle evaluated with inertial loads.” Journal of Neurophysiology. 80(6): 3369–3372, 1998.
- Lin, D.C. and Rymer, W.Z. “Mechanical properties of cat soleus muscle elicited by sequential ramp stretches: implications for control of muscle.” Journal of Neurophysiology. 90(3): 997–1008, 1993.
- Lin, D.C. and Rymer, W.Z. “A quantitative analysis of pendular motion of the lower leg in spastic human subjects.” IEEE Transactions on Biomedical Engineering. 38(9): 906–918, 1991.