The Gene and Linda Voiland School of

Chemical Engineering and Bioengineering

Bernard J. Van Wie, Ph.D.

Bernard Van Wie

Research Focus: Biosensors, Biomedical Processes, Mammalian Cell & Tissue Culture, Engineering Education

The Gene and Linda Voiland
School of Chemical Engineering and Bioengineering
1505 Stadium Way, Room 105
P.O. Box 646515
Washington State University
Pullman, WA 99164-6515

Office: 311 Wegner Hall (Tel: 509-335-4103)
Lab: ETRL 321 (Tel: 509-335-8099)
Dr. VanWie’s Curriculum Vitae

Graduate Students

Arshan Nazempour –MS Thesis: Hands-on Educational Innovations [funded by the National Science Foundation]; Recent PhD Thesis (2016): Cartilage Production and Cellular Mechanisms in a Centrifugal Bioreactor [funded by the National Science Foundation]
Jacqueline Burgher – PhD Thesis: Biomass Conversion and Classroom Implementation [funded by the National Science Foundation]
Negar Beheshti Pour – PhD Thesis: Hands-on Learning Heat Exchangers, Thermal Boundary Layer and Bubble Capture System [funded by the National Science Foundation]
Baran Arslan – Postdoctoral Associate: Biomanufacturing of Effector T-Cells for Cancer Therapy [funded by the National Science Foundation]
Olivia Ranft – Recently admitted MS Student: Ion Selective Electrodes for Detecting Cells and Proteins [funded by Washington State University Gap Fund]

Syllabi, Course Materials and Tutorials

Research Interests

Prof. Van Wie is engaged in research in various aspects of biotechnology including biosensors and bioanalytical devices, and cell and tissue culture. Also, he has been quite successful in the area of Engineering Education Research and currently is engaged in a second National Science Foundation Type II Course, Curriculum and Laboratory Improvement grant effort and interacts with several universities as a result including eight institutions in Nigeria where he and his family recently did a Fulbright exchange.

Biographical Information

Dr. Van Wie earned his Ph.D. in chemical engineering from the University of Oklahoma, Norman where he focused on blood-cell separations. He did postdoctoral work in the area of natural gas and Syngas properties and has completed two sabbaticals, one at Michigan State University and one at the Naval Research Laboratory. Both sabbaticals were focused on developing novel biosensors for medicine, biotechnology, and the environment. His current research focuses on bioprocessing and biomedical engineering with applications in biosensors and miniaturized diagnostic capabilities including designs at the micro and nanoscale, cell culture, and biomass processing. He is highly interested in effective teaching, and he along with graduates and the WSU Center for Teaching, Learning, and Technology, are working on new learning pedagogy which combines some of the best learning strategies together in a single course.

Awards/Honors Recieved

  • 2009 - Marian E. Smith Award for Unusually Innovative Teaching, Washington State University

Selected Publications

  1. Golter, PB, Brown, GR, Van Wie, BJ, "A Critical Thinking Instrument for Assessing Industrial Readiness", Submitted to J.STEM Ed.
  2. Paul Golter, Bernard Van Wie, Dave Thiessen, Jerome Babauta, Laura Coon, Shane Reynolds, William Schlecht, Sean Isacson, "Design and Technical Assessment of Hands-on Learning Desktop Modules", Submitted to Chemical Engineering Education.
  3. Abdul, B, Van Wie, BJ, Adesope, O, Brown, GR, Thiessen, DB. A Tale of Two Pedagogies Comparing Lecture and Active Learning in a Fluids and Heat Transfer Class, Submitted to Advances in Engr. Ed.
  4. Golter, PB, Brown, GR, Van Wie, BJ, Adoption of a Non-Lecture Pedagogy in Chemical Engineering: Insights Gained from Observing an Adopter, J STEM Ed., In Press 2012.
  5. Abdul, B, Golter, PB, Brown, GR, Babauta, JT, Bako, RB, Ahmed, A.S., Shide, EG, Anafi, FO, Olaofe, OO, Van Wie, BJ, "Miniaturized Industrial Process Equipment to Address Student Learning Barriers in Developing Nations: The Case of Nigeria", International Journal of Engineering Education, 27(1), 458476, 2011.
  6. Detzel, Christopher J. and Van Wie, Bernard J., "Use of a Centrifugal Bioreactor for Cartilaginous Tissue Formation from Isolated Chondrocytes", Biotechnology Progress, 27(2), 451459, 2011.
  7. Detzel, Christopher J.; Bernard J. Van Wie; and Cornelius F. Ivory, “Fluid Flow through a High Cell Density Fluidized Bed Fluidized-Bed during Centrifugal Bioreactor Culture”, Biotechnology Progress, 26, 1014–1023, 2010.
  8. Rieck, D.C.; Liu, B.; Park, B-J.; Moffett, D.F.; Kidwell, D.A.; Cheng, G.J.; Van Wie, B.J. “Functionalization of Micro- and Nano- Apertures with Chromate-Selective Solvent Polymeric Membrane”, Analytica Chimica Acta 659 (2010) 243–250. On-line version:
  9. Dewan, A.; Van Wie, B.; Lewandowski, B. & Beyenal, H. “Microbial Fuel Cells as an Education Tool”, Chemical Engineering Education, 44(2), 157–165, Spring 2010.
  10. Detzel, C.J.; Thorson, M.R.; Van Wie, B.J.; Ivory, C.F. “A Study of the Coriolis Effect on the Fluid Flow Profile in a Centrifugal Bioreactor”, Biotechnology Progress, 25(4), 1025–1034, 2009.
  11. Detzel, C.J.; Mason, D.J.; Davis, W.C.; Van Wie, B.J. “Kinetic Simulation of a Centrifugal Bioreactor for High Population Density Hybridoma Culture”, Biotechnology Progress, 25(6), 165–1659, 2009.
  12. Liu, B.; Rieck, D.; Van Wie, B.J.; Cheng, G.J.; Moffett, D.F.; Kidwell, D.A. “Bilayer Lipid Membrane(BLM) Based Ion Selective Electrodes at the Meso, Micro, and Nano Scales, Biosensors & Bioelectronics.” 24, 1843–1849, 2009.  On-line version:
  13. Harvey F. Doty, Bernard J. Van Wie, Gregory Hooks, Janet E. Ebaugh, Sarah J. Haarsma, Hajime Fuchida, Gary J. Cheng, Bingwen Liu, David A. Kidwell, Irenee R. Beattie, Burton D. Schmuck, “Enhancing Educational Motivation among Native High Schoolers: Cutting Edge Nanoscience Placed in an Environmental Water Quality Context,” Innovations 2007, W. Aung, et al. (eds.), iNEER, Arlington, VA, Chapter 44, pp. 484–493, 2007.
  14. Metallo, C.M., Mohr, J.C., Detzel, C.J., Van Wie, Bernard J. & Palecek, S.P., “Engineering the Stem Cell Microenvironment”, Biotechnology Progress, 23, 18–23, 2007.
  15. Plesha, MA, Van Wie, BJ, Mullin, JK & Kidwell, DA, “Measuring Quaternary Ammonium Cleaning Agents with Ion Selective Electrodes”, Analytica Chimica Acta, 570, 186–194, 2006.
  16. Golter, P.B., Van Wie, B.J., Scuderi, P.V., Henderson, T.W., Dueben, R.M., Brown, G.R., Thomson, W.J., “Combining Modern Learning Pedagogies in Fluid Mechanics and Heat Transfer” Annals of Research in Engineering Education, 2006 Summer Issue, Vol. 2, No. 2, 2006.
  17. Golter, P, Van Wie, B, Held, G, Windsor, J, “Practical Considerations for Miniaturized Hands-on Learning Stations”, Referred Conference Proceedings of the American Society for Engineering Education, Chicago, IL, June 19–22, 2006.
  18. Golter, P.B., Van Wie, B.J., Scuderi, P.V., Henderson, T.W., Dueben, R.M., Brown, G.R., Thomson, W.J., "Combining Modern Learning Pedagogies in Fluid Mechanics and Heat Transfer”, Chemical Engineering Education, 39, 280–287, 2005.
  19. Plesha, MA, Van Wie, BJ, Kidwell, DA, “Measuring Quaternary Ammonium Cleaning Agents with Ion Selective Electrodes” Revised Manuscript Submitted to Analytica Chimica Acta.
  20. Wu, X, Van Wie, BJ and Kidwell, DA, “An Enzyme Electrode for Amperometric Measurement of d-Amino Acid”, Biosensors & Bioelectronics, 20, 878–885, 2004.
  21. Wu, X, Detzel, CJ, Van Wie, BJ, Haarsma, SJ, and Kidwell, DA, “Model Based Optimization of Carbon Paste Enzyme Electrode”, Biotechnology & Bioengineering, 88, 204–213, 2004.
  22. Leatzow, D.M., Van Wie, B.J., Weyrauch, B.N., and Tiffany, T.O., “Design Optimization and Characterization of a Small-Scale Centrifugal Cell Separator”, Analytica Chimica Acta, 435, 299–307, 2001.
  23. Liu, G., Van Wie, B.J., Leatzow, D.M., Weyrauch, B.N., and Tiffany, T.O., “Experimental Design and Modeling of Carryover to Optimize Air-Segmented Continuous Flow Analysis”, Analytica Chimica Acta, 408, 21–31, 2000.
  24. Erickson, B.H., Van Wie, B.J., Leatzow, D.M., Liu, G., Thayer, P.C. and Tiffany, T.O., “Charge Coupled Device Optics System of Simultaneous Measurement of Multiple Reactions in a Microplate”, Clinical Chemistry, 44, 2046–2049, 1998.
  25. Yu, Y.-Y., Van Wie, B.J., Koch, A.R., Moffett, D.F., and Davis, W.C., “Real Time Analysis of Immunogen Complex Reactions Kinetics Using Surface Plasmon Resonance”, Analytical Biochemistry, 263, 158–168, 1998.
  26. Yu, Y.-Y., Van Wie, B.J., Koch, A.R., Moffett, D.F., and Davis, W.C., “Preparation and Characterization of Bifunctional Biopolymers for Receptor-Based Liposomal Immunosensing”, Biotechnology Progress, 14, 310–317, 1998.
  27. Parab, S., Van Wie, B.J., Byrnes, I., Robles, E.J., Weyrauch, B.N. and Tiffany, T.O., “Modeling & Optimization Studies for a Sequential Flow Based Bio-Analytical Module”, Analytica Chimica Acta, 359, 157–171, 1998.
  28. Yu, Y.-Y., Van Wie, B.J., Koch, A.R., Moffett, D.F., Davis, W.C., “Kinetic Modeling and Analysis of a Vesicle System for Immunosensor Development”, Biosensors & Bioelectronics, 12, 135–144, 1997.
  29. Reiken, S.R., Van Wie, B.J., Sutisna, H., Moffett, D.F., Koch, A.R., Silber, M., & Davis, W.C., “Bispecific Antibody Modification of Nicotinic Acetylcholine Receptors for Biosensing.” Biosensors & Bioelectronics, 11, 91–102, 1996.
  30. Eray, M., Dogan, N.S., Reiken, S.R., Sutisna, H., Van Wie, B.J., Koch, A.R., Moffett, D.F., Silber, M., and Davis, W.C., “A Highly Stable and Selective Biosensor Using Modified Nicotinic Acetylcholine Receptor (nAChR)”, BioSystems, 35, 183–188, 1995.
  31. Van Wie, B.J., Poshusta, J.C., Greenlee, R.D. and Brereton, R.A., “Fun Ways to Learn Fluid Mechanics and Heat Transfer”, Chemical Engineering Education, 28, 188–192, 1994.
  32. Reiken S.R., Van Wie, B.J., Sutisna, H., Kurdikar, D.L. and Davis, W.C., “Efficient Optimization of ELISAs”, J. Immunolog. Meth., 177, 199–205, 1994.
  33. Eray, M., Dogan, N.S., Liu, L., Koch, A.R., Moffett, D.F., Silber, M. and Van Wie, B.J., “Highly Stable Bilayer Lipid Membranes (BLMs) Formed on Microfabricated Polyimide Apertures and Their Electrical Characterization”, Biosensors and Bioelectronics, 9, 343–351, 1994.
  34. Skeen, R.S., Kurdikar, D.L. and Van Wie, B.J., “Modeling the Kinetics of Neuron-Based Chemical Sensing: Interactions Between Observable States”, Biosensors and Bioelectronics, 9, 265–274, 1994.
  35. Kurdikar, D.L., Skeen, R.S. and Van Wie, B.J., "Temperature Effects on Neuron-Based Chemical Sensing in Well-Mixed Flow Environments”, Analytica Chimica Acta, 262, 1–12, 1992.
  36. Skeen, R.S., Van Wie, B.J., Fung, S.J. and Barnes, C.D., “Effects of Temperature and Analyte Application Technique on Neuron-Based Chemical Sensing”, Biosensors and Bioelectronics, 7, 91, 1992.
  37. Skeen, R.S., Van Wie, B.J., Fung, S.J. and Barnes, C.D., “Application of Compiled BASIC in Developing Software for Electrophysiology”, J. Neuroscience Methods, 41, 113–121, 1992.
  38. Kurdikar, D.L., Skeen, R.S., Van Wie, B.J., Barnes, C.D. and Fung, S.J., “Whole Cell Biosensors: A Brief Overview and Presentation of A Novel Neuron-based Approach”, In: Frontiers in Bioprocessing II, eds. Todd, P., Sikdar, S.K., and Bier, M., pp. 126–137, 1992.
  39. Wooten, S.L., Petersen, J.N. and Van Wie, B.J., “Complete Computer Control of Apheresis Procedures Performed in a COBE 2997 Cell Separator”, Biomechanical Engineering, 113, 11–20, 1991.
  40. Van Wie, B.J., Brouns, T.M., Elliott, M.L. and Davis, W.C., “A Novel Continuous Centrifugal Bioreactor for High Density Cultivation of Mammalian and Microbial Cells”, Biotechnology and Bioengineering, 38, 1190–1202, 1991.
  41. Skeen, R.S., Kisaalita, W.S., Van Wie, B.J., Fung, S.J. and Barnes, C.D., “Evaluation of a Neuron-Based Sensing with Neurotransmitter Serotonin”, Biosensors and Bioelectronics, 5, 491–510, 1990.
  42. Skeen, R.S., Kisaalita, W.S., Van Wie, B.J., Fung, S.J., and Barnes, C. D., “Serotonin Sensing Properties of Identified Invertebrate Neurons”, Biosensor Technology Fundamentals and Applications, eds: Buck, R.P., Hatfield, W.E., Umana, M. and Bowden, E.F., Marcel Dekker, Inc., New York and Basel, pp 63–69, 1990.
  43. Kisaalita, W.S., Van Wie, BJ., Skeen, R.S., Davis, W.C., Barnes, C.D., Fung, S.J., Chun, K. and Dogan, N. S., “Initiating Crossdisciplinary Research: The Neuron Based Chemical Sensor Project”, Chemical Engineering Education, 23, 242–249, 1989.
  44. Van Wie, B.J., Langenberg, M.A. Chang, W.C. W., Kumar, K.H. and Starling, K.E., “Evaluation of Data Availability and Quality for Interaction Second Virial Coefficients of Use to the Gas Industry”, U.S. Department of Commerce, National Bureau of Standards, Technical Note, U.S. Government Printing Office, Washington D.C., 1988.
  45. Oxford, R.J., Petersen, J.N., Van Wie, B.J., Wooten, S.L. and Schneider, G.W., “Interface Dynamics in a COBE 2997 Centrifugal Cell Separator"”, Transfusion, 28, 588–592, 1988.
  46. Van Wie, B.J. and Hustvedt, E.L., “Particle Interaction Effects on Blood Cell Sedimentation and Separations”, Biorheology, 25, 651–662, 1988.
  47. Drumheller, P.D., Van Wie, B.J., Petersen, J.N., Oxford, R.J. and Schneider, G.W., “The Effects of RPM and Recycle on Separation Efficiency in a Clinical Blood Cell Centrifuge”, Journal of Biomechanical Engineering, 109, 324–329, 1987.
  48. Van Wie, B.J., Elliott, M.L. and Lee, J.M., “Development and Characterization of a Continuous Centrifugal Bio Reactor”, Biotechnology and Bioengineering Symposium, 17, 335–344, 1986.
  49. Van Wie, B.J. and Sofer, S.S., “Experimental Considerations for the Centrifugal Separation of Blood Cell Components”, The International Journal of Artificial Organs, 9, 49–58, 1986.
  50. Van Wie, B.J. and Sofer, S.S., “The Effect of Recycle on the Continuous Processing of Blood Cells”, The International Journal of Artificial Organs (IJAO), 8, 43–48, 1985.
  51. Van Wie, B.J. and Sofer, S.S., “Stagewise Separations to Improve Continuous Centrifugal Blood Cell Separators”, IJAO, 8, 49 54, 1985.
  52. Van Wie, B.J. and Sofer, S.S., “Sedimentation Theory and Practical Considerations for the Design of Centrifugal Blood Cell Processes”, IJAO, 8, 215–222, 1985.
  53. Sofer, S.S., Wills, R.A. and Van Wie, B.J., “A Model Enzymic Extracorporeal Detoxification System”, Artif. Organs, 3, 127–131, 1979.

Nigerian students working in the classroom

Professor Van Wie’s Hands-on Active classroom in Nigeria since the work has been funded by a major World Bank grant to disseminate the teaching methods throughout Nigeria.

WSU students working in classroom

Students engaged with Desktop Learning Modules developed by Prof. Van Wie and colleagues at Washington State University under sponsorship by the National Science Foundation.

The Gene & Linda Voiland School of Chemical Engineering and Bioengineering, PO Box 646515, Washington State University, Pullman WA 99164-6515, 509-335-4332, Email ChEBE: